![]() ![]() Probiotic supplementation has been hypothesized to affect innate and adaptive immune responses to environmental antigens by supporting healthy gut microbiota, and could therefore be used to prevent the onset of T1D-associated islet autoimmunity and treat the established disease. In humans, early probiotic administration could decrease the risk of islet autoimmune reactions in children, with high genetic risk to develop the disease. Lactobacillus and Bifidobacterium are important genera in the colon microbiota of humans. Beneficial effects of Lactobacillus rhamnosus and Bifidobacterium lactis on β-cell function would create a rationale for its use in patients with newly diagnosed T1D. īernhard Holzmann, in Encyclopedia of Immunobiology, 2016 Autoimmune Diseases Bacteriotherapy is a potential tool to modulate the immune system in the prevention of islet cell autoimmunity. The functions of CGRP in autoimmune diabetes were studied in NOD mice with transgenic expression of CGRP in pancreatic β cells ( Khachatryan et al., 1997). Local production of CGRP markedly reduced the incidence of diabetes and the development of peri-insulitis, but did not lead to systemic effects. Similarly, CGRP gene transfer decreased the morbidity of diabetes caused by multiple injections of low-dose streptozocin and inhibited lymphocyte infiltration into the islets ( Sun et al., 2003). ![]() However, in this model, the systemic release of CGRP was found to alter splenic T cell responses leading to impaired proliferation and IFNγ production, and to an increased release of IL-10. Ramp1-deficient mice show an attenuated development of experimental allergic encephalomyelitis after immunization with myelin oligodendrocyte glycoprotein peptide ( Mikami et al., 2012). Th17 cells are considered important for induction of this autoimmune disease ( Bettelli et al., 2007 Ouyang et al., 2008). Delli, Åke Lernmark, in Endocrinology: Adult and Pediatric (Seventh Edition), 2016 Prevention Interestingly, the release of IL-17 was markedly reduced in CD4 T cells from diseased Ramp1-deficient mice suggesting that CGRP enhances the development of experimental allergic encephalomyelitis by promoting IL-17 production.Īhmed J. The ability to prevent or reverse autoimmune diabetes in laboratory animals such as the NOD mouse and BB rat using different therapeutic approaches has initiated several prevention and intervention studies in humans. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |