![]() ![]() Disagreement was quantified using RAND/UCLA Appropriateness Method.įor the management of cardiac arrest, we recommend using ILE with bupivacaine toxicity, while our recommendations are neutral regarding its use for all other toxins. A two-round modified Delphi method was used to reach consensus on the voting statements. Voting statements were proposed using a predetermined format. Twenty-two toxins or toxin categories and three clinical situations were selected for voting. A collaborative workgroup appraised the literature and provides evidence-based recommendations for the use of ILE in poisoning.įollowing a systematic review of the literature, data were summarized in four publications: LA and non-LA poisoning efficacy, adverse effects, and analytical interferences. 23 w Department of Medical Biology, Sacré-Coeur Hospital, University of Montréal, Montréal, Québec, Canada.Īlthough intravenous lipid emulsion (ILE) was first used to treat life-threatening local anesthetic (LA) toxicity, its use has expanded to include both non-local anesthetic (non-LA) poisoning and less severe manifestations of toxicity.22 v Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.21 u Department of Medical and Toxicological Intensive Care, Lariboisière Hospital, Paris-Diderot University, INSERM UMRS1144, Paris, France.20 t St Luke's Roosevelt Hospital, New York, NY, USA.19 s Department of Emergency Medicine, Division of Clinical Pharmacology and Toxicology, University of Calgary, Poison and Drug Information Service, Calgary, Alberta, Canada.18 r Medical Toxicology, Department of Emergency Medicine, Morristown Medical Center, Emergency Medical Associates, Morristown, NJ, USA.17 q Centre Antipoison du Québec, Quebec, Canada.16 p Division of Emergency Medicine, Department of Pediatrics, CHU Sainte-Justine, Montréal, Québec, Canada.15 o Division of Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, and CHU de Québec, Université Laval Research Center, Population Health and Optimal Health Practices Unit, Université Laval, Québec City, Québec, Canada.14 n Schulich Library of Science and Engineering, McGill University, Montréal, Québec, Canada.13 m Department of Emergency Medicine, Section of Medical Toxicology, University of Southern California, Los Angeles, CA, USA.12 l Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.11 k Department of Pharmacy, University of Maryland Medical Center, Baltimore, MD, USA.10 j Department of Emergency Medicine, Regions Hospital, Saint Paul, MN, USA.9 i National Poisons Information Service (Newcastle) and Medical Toxicology Centre, Institute of Cellular Medicine, Newcastle University, Newcastle, UK.8 h Department of Emergency Medicine, Upstate Medical University, Syracuse, New York, USA.7 g Upstate NY Poison Center, Syracuse, NY, USA. ![]() 6 f Monash Clinical Toxicology Service, Program of Emergency Medicine, Monash Health and School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia.Perelman Department of Emergency Medicine, New York University School of Medicine, New York, NY, USA. 5 e Division of Medical Toxicology, Ronald O.4 d Danish Poisons Information Centre, Anaesthesiology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark.3 c Province of Alberta Drug Information Services, Calgary, Alberta, Canada.2 b Centre Antipoison du Québec, Montréal, Québec, Canada.1 a Department of Emergency Medicine, McGill University Health Centre, Montréal, Québec, Canada. ![]()
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